A good program to take a screenshot easily and efficiently is a must have. I settled on Flameshot for it's simplicity as well as having the ability to upload to imgur. I do wish it could upload to a Nextcloud instance (Like ShareX) but alas it does not.
To install on Pop-OS! and other ubuntu flavours use the following:
sudo apt install flameshot
I use a custom shortcut to enable one-key press screenshots and in Pop-OS! this is simply done in the settings menu .
See below image -
The command is:
/usr/bin/flameshot gui